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Cysteine dioxygenase structures from pH 4 to 9: consistent Cys-persulfenate formation at intermediate pH and a Cys-bound enzyme at higher pH

Mammalian cysteine dioxygenase (CDO) is a mononuclear non-heme iron protein that catalyzes the conversion of cysteine (Cys) to cysteine sulfinic acid (CSA) by an unclarified mechanism. One structural study revealed a Cys-persulfenate (or Cys-persulfenic acid) formed in the active site, but quantum m...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Driggers, Camden M., Cooley, Richard B., Sankaran, Banumathi, Hirschberger, Lawrence L., Stipanuk, Martha H., Karplus, P. Andrew
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3744157/
https://ncbi.nlm.nih.gov/pubmed/23747973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.05.028
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