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Effect of epigenetic histone modifications on E-cadherin splicing and expression in lung cancer

We have identified an alternatively spliced, non-functional aberrant E-cadherin transcript that lacks exon 11 and is over expressed in malignant cells as compared to the normal non-malignant cells. This increase in the aberrant transcript is a mechanism of loss of E-cadherin gene expression as it is...

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Autors principals: Liao, Wei, Jordaan, Gwen, Srivastava, Minu K, Dubinett, Steven, Sharma, Sherven, Sharma, Sanjai
Format: Artigo
Idioma:Inglês
Publicat: e-Century Publishing Corporation 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3744017/
https://ncbi.nlm.nih.gov/pubmed/23977447
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