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Structural Determinants of Oligomerization of !(1)-Pyrroline-5-Carboxylate Dehydrogenase: Identification of a Hexamerization Hot Spot
The aldehyde dehydrogenase (ALDH) superfamily member !(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH) catalyzes the NAD(+)-dependent oxidation of glutamate semialdehyde to glutamate, which is the final step of proline catabolism. Defects in P5CDH activity lead to the metabolic disorder type II hyp...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3743950/ https://ncbi.nlm.nih.gov/pubmed/23747974 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.05.027 |
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