Absence of Functional Leptin Receptor Isoforms in the POUND (Lepr(db/lb)) Mouse Is Associated with Muscle Atrophy and Altered Myoblast Proliferation and Differentiation

OBJECTIVE: Leptin receptors are abundant in human skeletal muscle, but the role of leptin in muscle growth, development and aging is not well understood. Here we utilized a novel mouse model lacking all functional leptin receptor isoforms (POUND mouse, Lepr(db/lb)) to determine the role of leptin in...

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Main Authors: Arounleut, Phonepasong, Bowser, Matthew, Upadhyay, Sunil, Shi, Xing-Ming, Fulzele, Sadanand, Johnson, Maribeth H., Stranahan, Alexis M., Hill, William D., Isales, Carlos M., Hamrick, Mark W.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3743798/
https://ncbi.nlm.nih.gov/pubmed/23967295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072330
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