Uric acid induces caspase-1 activation, IL-1β secretion and P2X7 receptor dependent proliferation in primary human lymphocytes

Background: Urate through Nacht Domain, Leucine-Rich Repeat, and pyrin domain-containing protein 3 (NALP3) dependent caspase-1 activation stimulates macrophages to secrete inteleukin-1β (IL-1β). Purinergic receptor P2X7 plays a role in the urate induced NALP3 activation. Urate also enhances adaptive...

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Detalhes bibliográficos
Main Authors: Eleftheriadis, T, Pissas, G, Karioti, A, Antoniadi, G, Golfinopoulos, S, Liakopoulos, V, Mamara, A, Speletas, M, Koukoulis, G, Stefanidis, I
Formato: Artigo
Idioma:Inglês
Publicado em: SOCIETY OF "FRIENDS OF HIPPOKRATIA JOURNAL" 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3743618/
https://ncbi.nlm.nih.gov/pubmed/24376319
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