β(2)-Glycoprotein I binds factor XI and inhibits its activation by thrombin and factor XIIa: Loss of inhibition by clipped β(2)-glycoprotein I

Activation of factor XI (FXI) by thrombin in vivo plays a role in coagulation by providing an important positive feedback mechanism for additional thrombin generation. FXI is activated in vitro by thrombin, or FXIIa in the presence of dextran sulfate. In this report, we investigated the effect of β(...

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Detalhes bibliográficos
Main Authors: Shi, Tong, Iverson, G. Michael, Qi, Jian C., Cockerill, Keith A., Linnik, Matthew D., Konecny, Pamela, Krilis, Steven A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC374348/
https://ncbi.nlm.nih.gov/pubmed/15007174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400281101
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