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Structure and Catalytic Mechanism of Yeast 4-Amino-4-deoxychorismate Lyase

Saccharomyces cerevisiae Abz2 is a pyridoxal 5′-phosphate (PLP)-dependent lyase that converts 4-amino-4-deoxychorismate (ADC) to para-aminobenzoate and pyruvate. To investigate the catalytic mechanism, we determined the 1.9 Å resolution crystal structure of Abz2 complexed with PLP, representing the...

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Detalhes bibliográficos
Main Authors: Dai, Ya-Nan, Chi, Chang-Biao, Zhou, Kang, Cheng, Wang, Jiang, Yong-Liang, Ren, Yan-Min, Ruan, Ke, Chen, Yuxing, Zhou, Cong-Zhao
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3743474/
https://ncbi.nlm.nih.gov/pubmed/23818518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.480335
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