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Structure and Catalytic Mechanism of Yeast 4-Amino-4-deoxychorismate Lyase
Saccharomyces cerevisiae Abz2 is a pyridoxal 5′-phosphate (PLP)-dependent lyase that converts 4-amino-4-deoxychorismate (ADC) to para-aminobenzoate and pyruvate. To investigate the catalytic mechanism, we determined the 1.9 Å resolution crystal structure of Abz2 complexed with PLP, representing the...
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Main Authors: | , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Society for Biochemistry and Molecular Biology
2013
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3743474/ https://ncbi.nlm.nih.gov/pubmed/23818518 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.480335 |
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