Chronic Activation of mTOR Complex 1 is Sufficient to Cause Hepatocellular Carcinoma

The mammalian target of rapamycin (mTOR) complex 1 (mTORC1) is a nutrient sensitive protein kinase that is aberrantly activated in many human cancers. However, whether dysregulation of mTORC1 signaling in normal tissues contributes to cancer risk is unknown. Here, we focused on hepatocellular carcin...

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Autori principali: Menon, Suchithra, Yecies, Jessica L., Zhang, Hui H., Howell, Jessica J., Nicholatos, Justin, Harputlugil, Eylul, Bronson, Roderick T., Kwiatkowski, David J., Manning, Brendan D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3743103/
https://ncbi.nlm.nih.gov/pubmed/22457330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2002739
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