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Chronic Activation of mTOR Complex 1 is Sufficient to Cause Hepatocellular Carcinoma
The mammalian target of rapamycin (mTOR) complex 1 (mTORC1) is a nutrient sensitive protein kinase that is aberrantly activated in many human cancers. However, whether dysregulation of mTORC1 signaling in normal tissues contributes to cancer risk is unknown. Here, we focused on hepatocellular carcin...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3743103/ https://ncbi.nlm.nih.gov/pubmed/22457330 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2002739 |
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