An RNA-seq Protocol to Identify mRNA Expression Changes in Mouse Diaphyseal Bone: Applications in Mice with Bone Property Altering Lrp5 Mutations

Loss-of-function and certain missense mutations in the Wnt co-receptor LRP5 significantly decrease or increase bone mass, respectively. These human skeletal phenotypes have been recapitulated in mice harboring Lrp5 knockout and knockin mutations. We hypothesized that measuring mRNA expression in dia...

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Main Authors: Ayturk, Ugur M., Jacobsen, Christina M., Christodoulou, Danos C., Gorham, Joshua, Seidman, Jonathan G., Seidman, Christine E., Robling, Alexander G., Warman, Matthew L.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3743099/
https://ncbi.nlm.nih.gov/pubmed/23553928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.1946
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