The Ribonucleotide Reductase R1 Homolog of Murine Cytomegalovirus Is Not a Functional Enzyme Subunit but Is Required for Pathogenesis

Ribonucleotide reductase (RNR) is the key enzyme in the biosynthesis of deoxyribonucleotides. Alpha- and gammaherpesviruses express a functional enzyme, since they code for both the R1 and the R2 subunits. By contrast, betaherpesviruses contain an open reading frame (ORF) with homology to R1, but an...

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Detalhes bibliográficos
Main Authors: Lembo, David, Donalisio, Manuela, Hofer, Anders, Cornaglia, Maura, Brune, Wolfram, Koszinowski, Ulrich, Thelander, Lars, Landolfo, Santo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC374293/
https://ncbi.nlm.nih.gov/pubmed/15047841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.8.4278-4288.2004
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