The Ribonucleotide Reductase R1 Homolog of Murine Cytomegalovirus Is Not a Functional Enzyme Subunit but Is Required for Pathogenesis

Ribonucleotide reductase (RNR) is the key enzyme in the biosynthesis of deoxyribonucleotides. Alpha- and gammaherpesviruses express a functional enzyme, since they code for both the R1 and the R2 subunits. By contrast, betaherpesviruses contain an open reading frame (ORF) with homology to R1, but an...

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Bibliografski detalji
Izdano u:J Virol
Glavni autori: Lembo, David, Donalisio, Manuela, Hofer, Anders, Cornaglia, Maura, Brune, Wolfram, Koszinowski, Ulrich, Thelander, Lars, Landolfo, Santo
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2004
Teme:
Virus-Cell Interactions
Online pristup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC374293/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15047841/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.8.4278-4288.2004
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