The Human Cytomegalovirus Ribonucleotide Reductase Homolog UL45 Is Dispensable for Growth in Endothelial Cells, as Determined by a BAC-Cloned Clinical Isolate of Human Cytomegalovirus with Preserved Wild-Type Characteristics

An endothelial cell-tropic and leukotropic human cytomegalovirus (HCMV) clinical isolate was cloned as a fusion-inducing factor X-bacterial artificial chromosome in Escherichia coli, and the ribonucleotide reductase homolog UL45 was deleted. Reconstituted virus RVFIX and RVΔUL45 grew equally well in...

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Pubblicato in:	J Virol
Autori principali:	Hahn, Gabriele, Khan, Hanna, Baldanti, Fausto, Koszinowski, Ulrich H., Revello, M. Grazia, Gerna, Giuseppe
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2002
Soggetti:	Virus-Cell Interactions
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136448/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12186938/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.18.9551-9555.2002
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