The Human Cytomegalovirus Ribonucleotide Reductase Homolog UL45 Is Dispensable for Growth in Endothelial Cells, as Determined by a BAC-Cloned Clinical Isolate of Human Cytomegalovirus with Preserved Wild-Type Characteristics

An endothelial cell-tropic and leukotropic human cytomegalovirus (HCMV) clinical isolate was cloned as a fusion-inducing factor X-bacterial artificial chromosome in Escherichia coli, and the ribonucleotide reductase homolog UL45 was deleted. Reconstituted virus RVFIX and RVΔUL45 grew equally well in...

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Bibliographic Details
Main Authors: Hahn, Gabriele, Khan, Hanna, Baldanti, Fausto, Koszinowski, Ulrich H., Revello, M. Grazia, Gerna, Giuseppe
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC136448/
https://ncbi.nlm.nih.gov/pubmed/12186938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.18.9551-9555.2002
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