Constitutively-active androgen receptor variants function independently of the HSP90 chaperone but do not confer resistance to HSP90 inhibitors

The development of lethal, castration resistant prostate cancer is associated with adaptive changes to the androgen receptor (AR), including the emergence of mutant receptors and truncated, constitutively active AR variants. AR relies on the molecular chaperone HSP90 for its function in both normal...

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Autores principales: Gillis, Joanna L., Selth, Luke A., Centenera, Margaret M., Townley, Scott L., Sun, Shihua, Plymate, Stephen R., Tilley, Wayne D., Butler, Lisa M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2013
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3742830/
https://ncbi.nlm.nih.gov/pubmed/23674566
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