Fine-Mapping, Gene Expression and Splicing Analysis of the Disease Associated LRRK2 Locus

Association studies have identified several signals at the LRRK2 locus for Parkinson's disease (PD), Crohn's disease (CD) and leprosy. However, little is known about the molecular mechanisms mediating these effects. To further characterize this locus, we fine-mapped the risk association in...

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Main Authors: Trabzuni, Daniah, Ryten, Mina, Emmett, Warren, Ramasamy, Adaikalavan, Lackner, Karl J., Zeller, Tanja, Walker, Robert, Smith, Colin, Lewis, Patrick A., Mamais, Adamantios, de Silva, Rohan, Vandrovcova, Jana, Hernandez, Dena, Nalls, Michael A., Sharma, Manu, Garnier, Sophie, Lesage, Suzanne, Simon-Sanchez, Javier, Gasser, Thomas, Heutink, Peter, Brice, Alexis, Singleton, Andrew, Cai, Huaibin, Schadt, Eric, Wood, Nicholas W., Bandopadhyay, Rina, Weale, Michael E., Hardy, John, Plagnol, Vincent
格式: Artigo
語言:Inglês
出版: Public Library of Science 2013
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3742662/
https://ncbi.nlm.nih.gov/pubmed/23967090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070724
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