Fine-Mapping, Gene Expression and Splicing Analysis of the Disease Associated LRRK2 Locus

Association studies have identified several signals at the LRRK2 locus for Parkinson's disease (PD), Crohn's disease (CD) and leprosy. However, little is known about the molecular mechanisms mediating these effects. To further characterize this locus, we fine-mapped the risk association in...

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Detalhes bibliográficos
Main Authors: Trabzuni, Daniah, Ryten, Mina, Emmett, Warren, Ramasamy, Adaikalavan, Lackner, Karl J., Zeller, Tanja, Walker, Robert, Smith, Colin, Lewis, Patrick A., Mamais, Adamantios, de Silva, Rohan, Vandrovcova, Jana, Hernandez, Dena, Nalls, Michael A., Sharma, Manu, Garnier, Sophie, Lesage, Suzanne, Simon-Sanchez, Javier, Gasser, Thomas, Heutink, Peter, Brice, Alexis, Singleton, Andrew, Cai, Huaibin, Schadt, Eric, Wood, Nicholas W., Bandopadhyay, Rina, Weale, Michael E., Hardy, John, Plagnol, Vincent
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3742662/
https://ncbi.nlm.nih.gov/pubmed/23967090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070724
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