Fine-Mapping, Gene Expression and Splicing Analysis of the Disease Associated LRRK2 Locus

Association studies have identified several signals at the LRRK2 locus for Parkinson's disease (PD), Crohn's disease (CD) and leprosy. However, little is known about the molecular mechanisms mediating these effects. To further characterize this locus, we fine-mapped the risk association in...

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Autores principales: Trabzuni, Daniah, Ryten, Mina, Emmett, Warren, Ramasamy, Adaikalavan, Lackner, Karl J., Zeller, Tanja, Walker, Robert, Smith, Colin, Lewis, Patrick A., Mamais, Adamantios, de Silva, Rohan, Vandrovcova, Jana, Hernandez, Dena, Nalls, Michael A., Sharma, Manu, Garnier, Sophie, Lesage, Suzanne, Simon-Sanchez, Javier, Gasser, Thomas, Heutink, Peter, Brice, Alexis, Singleton, Andrew, Cai, Huaibin, Schadt, Eric, Wood, Nicholas W., Bandopadhyay, Rina, Weale, Michael E., Hardy, John, Plagnol, Vincent
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3742662/
https://ncbi.nlm.nih.gov/pubmed/23967090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070724
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