Repression of Tax Expression Is Associated both with Resistance of Human T-Cell Leukemia Virus Type 1-Infected T Cells to Killing by Tax-Specific Cytotoxic T Lymphocytes and with Impaired Tumorigenicity in a Rat Model

Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL). Although the viral transactivation factor, Tax, has been known to have apparent transforming ability, the exact function of Tax in ATL development is still not clear. To understand the role of Tax in ATL development, we...

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Detalhes bibliográficos
Main Authors: Nomura, Machiko, Ohashi, Takashi, Nishikawa, Keiko, Nishitsuji, Hironori, Kurihara, Kiyoshi, Hasegawa, Atsuhiko, Furuta, Rika A., Fujisawa, Jun-ichi, Tanaka, Yuetsu, Hanabuchi, Shino, Harashima, Nanae, Masuda, Takao, Kannagi, Mari
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2004
Assuntos:
Transformation and Oncogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC374260/
https://ncbi.nlm.nih.gov/pubmed/15047798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.8.3827-3836.2004
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