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Histone deacetylase inhibitors modulate miRNA and mRNA expression, block metaphase, and induce apoptosis in inflammatory breast cancer cells

To develop new therapies for inflammatory breast cancer (IBC) we have compared the effects of two hydroxamic acid-based histone deacetylase (HDAC) inhibitors, CG-1521 and Trichostatin A (TSA) on the biology of two IBC cell lines: SUM149PT and SUM190PT. CG-1521 and TSA induce dose (0−10 µM) and time-...

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Main Authors: Chatterjee, Namita, Wang, Wei-Lin Winnie, Conklin, Tucker, Chittur, Sridar, Tenniswood, Martin
格式: Artigo
語言:Inglês
出版: Landes Bioscience 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3742495/
https://ncbi.nlm.nih.gov/pubmed/23792638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.25088
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