Filaggrin-dependent secretion of sphingomyelinase protects against staphylococcal α-toxin–induced keratinocyte death

BACKGROUND: The skin of patients with atopic dermatitis (AD) has defects in keratinocyte differentiation, particularly in expression of the epidermal barrier protein filaggrin. AD skin lesions are often exacerbated by Staphylococcus aureus–mediated secretion of the virulence factor α-toxin. It is un...

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Detalhes bibliográficos
Main Authors: Brauweiler, Anne M., Bin, Lianghua, Kim, Byung Eui, Oyoshi, Michiko K., Geha, Raif S., Goleva, Elena, Leung, Donald Y. M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3742335/
https://ncbi.nlm.nih.gov/pubmed/23246020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2012.10.030
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