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Specificity of microRNA target selection in translational repression

MicroRNAs (miRNAs) are a class of noncoding RNAs found in organisms as evolutionarily distant as plants and mammals, yet most of the mRNAs they regulate are unknown. Here we show that the ability of an miRNA to translationally repress a target mRNA is largely dictated by the free energy of binding o...

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Udgivet i:Genes Dev
Principais autores: Doench, John G., Sharp, Phillip A.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2004
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC374233/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15014042/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1184404
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