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MEK drives cyclin D1 hyperelevation during geroconversion
When the cell cycle becomes arrested, MTOR (mechanistic Target of Rapamycin) converts reversible arrest into senescence (geroconversion). Hyperexpression of cyclin D1 is a universal marker of senescence along with hypertrophy, beta-Gal staining and loss of replicative/regenerative potential (RP), na...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3741510/ https://ncbi.nlm.nih.gov/pubmed/23852369 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.86 |
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