Autophagy Inhibition with Monensin Enhances Cell Cycle Arrest and Apoptosis Induced by mTOR or Epidermal Growth Factor Receptor Inhibitors in Lung Cancer Cells

BACKGROUND: In cancer cells, autophagy is generally induced as a pro-survival mechanism in response to treatment-associated genotoxic and metabolic stress. Thus, concurrent autophagy inhibition can be expected to have a synergistic effect with chemotherapy on cancer cell death. Monensin, a polyether...

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Hlavní autoři: Choi, Hyeong Sim, Jeong, Eun-Hui, Lee, Tae-Gul, Kim, Seo Yun, Kim, Hye-Ryoun, Kim, Cheol Hyeon
Médium: Artigo
Jazyk:Inglês
Vydáno: The Korean Academy of Tuberculosis and Respiratory Diseases 2013
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3741474/
https://ncbi.nlm.nih.gov/pubmed/23946753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4046/trd.2013.75.1.9
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