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Transcript Profiling Identifies Iqgap2(−/−) Mouse as a Model for Advanced Human Hepatocellular Carcinoma

It is broadly accepted that genetically engineered animal models do not always recapitulate human pathobiology. Therefore identifying best-fit mouse models of human cancers that truly reflect the corresponding human disease is of vital importance in elucidating molecular mechanisms of tumorigenesis...

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Bibliographic Details
Main Authors: Gnatenko, Dmitri V., Xu, Xiao, Zhu, Wei, Schmidt, Valentina A.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3741273/
https://ncbi.nlm.nih.gov/pubmed/23951254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071826
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