Aberrant promoter hypermethylation of PBRM1, BAP1, SETD2, KDM6A and other chromatin-modifying genes is absent or rare in clear cell RCC

Recent sequencing studies of clear cell (conventional) renal cell carcinoma (ccRCC) have identified inactivating point mutations in the chromatin-modifying genes PBRM1, KDM6A/UTX, KDM5C/JARID1C, SETD2, MLL2 and BAP1. To investigate whether aberrant hypermethylation is a mechanism of inactivation of...

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Bibliografiska uppgifter
Huvudupphovsmän: Ibragimova, Ilsiya, Maradeo, Marie E., Dulaimi, Essel, Cairns, Paul
Materialtyp: Artigo
Språk:Inglês
Publicerad: Landes Bioscience 2013
Ämnen:
Brief Report
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3741218/
https://ncbi.nlm.nih.gov/pubmed/23644518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.24552
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