Persistent Overexpression of Phosphoglycerate Mutase, a Glycolytic Enzyme, Modifies Energy Metabolism and Reduces Stress Resistance of Heart in Mice

BACKGROUND: Heart failure is associated with changes in cardiac energy metabolism. Glucose metabolism in particular is thought to be important in the pathogenesis of heart failure. We examined the effects of persistent overexpression of phosphoglycerate mutase 2 (Pgam2), a glycolytic enzyme, on card...

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Hauptverfasser: Okuda, Junji, Niizuma, Shinnichiro, Shioi, Tetsuo, Kato, Takao, Inuzuka, Yasutaka, Kawashima, Tsuneaki, Tamaki, Yodo, Kawamoto, Akira, Tanada, Yohei, Iwanaga, Yoshitaka, Narazaki, Michiko, Matsuda, Tetsuya, Adachi, Souichi, Soga, Tomoyoshi, Takemura, Genzou, Kondoh, Hiroshi, Kita, Toru, Kimura, Takeshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3741204/
https://ncbi.nlm.nih.gov/pubmed/23951293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072173
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