Persistent Overexpression of Phosphoglycerate Mutase, a Glycolytic Enzyme, Modifies Energy Metabolism and Reduces Stress Resistance of Heart in Mice

BACKGROUND: Heart failure is associated with changes in cardiac energy metabolism. Glucose metabolism in particular is thought to be important in the pathogenesis of heart failure. We examined the effects of persistent overexpression of phosphoglycerate mutase 2 (Pgam2), a glycolytic enzyme, on card...

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Autores principales: Okuda, Junji, Niizuma, Shinnichiro, Shioi, Tetsuo, Kato, Takao, Inuzuka, Yasutaka, Kawashima, Tsuneaki, Tamaki, Yodo, Kawamoto, Akira, Tanada, Yohei, Iwanaga, Yoshitaka, Narazaki, Michiko, Matsuda, Tetsuya, Adachi, Souichi, Soga, Tomoyoshi, Takemura, Genzou, Kondoh, Hiroshi, Kita, Toru, Kimura, Takeshi
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3741204/
https://ncbi.nlm.nih.gov/pubmed/23951293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072173
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