Persistent Overexpression of Phosphoglycerate Mutase, a Glycolytic Enzyme, Modifies Energy Metabolism and Reduces Stress Resistance of Heart in Mice

BACKGROUND: Heart failure is associated with changes in cardiac energy metabolism. Glucose metabolism in particular is thought to be important in the pathogenesis of heart failure. We examined the effects of persistent overexpression of phosphoglycerate mutase 2 (Pgam2), a glycolytic enzyme, on card...

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Main Authors: Okuda, Junji, Niizuma, Shinnichiro, Shioi, Tetsuo, Kato, Takao, Inuzuka, Yasutaka, Kawashima, Tsuneaki, Tamaki, Yodo, Kawamoto, Akira, Tanada, Yohei, Iwanaga, Yoshitaka, Narazaki, Michiko, Matsuda, Tetsuya, Adachi, Souichi, Soga, Tomoyoshi, Takemura, Genzou, Kondoh, Hiroshi, Kita, Toru, Kimura, Takeshi
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3741204/
https://ncbi.nlm.nih.gov/pubmed/23951293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072173
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