Persistent Overexpression of Phosphoglycerate Mutase, a Glycolytic Enzyme, Modifies Energy Metabolism and Reduces Stress Resistance of Heart in Mice

BACKGROUND: Heart failure is associated with changes in cardiac energy metabolism. Glucose metabolism in particular is thought to be important in the pathogenesis of heart failure. We examined the effects of persistent overexpression of phosphoglycerate mutase 2 (Pgam2), a glycolytic enzyme, on card...

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Detalhes bibliográficos
Main Authors: Okuda, Junji, Niizuma, Shinnichiro, Shioi, Tetsuo, Kato, Takao, Inuzuka, Yasutaka, Kawashima, Tsuneaki, Tamaki, Yodo, Kawamoto, Akira, Tanada, Yohei, Iwanaga, Yoshitaka, Narazaki, Michiko, Matsuda, Tetsuya, Adachi, Souichi, Soga, Tomoyoshi, Takemura, Genzou, Kondoh, Hiroshi, Kita, Toru, Kimura, Takeshi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3741204/
https://ncbi.nlm.nih.gov/pubmed/23951293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072173
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