Variant in the sequence of the LINGO1 gene confers risk of essential tremor

We identified a marker in LINGO1 showing genome-wide significant association (P = 1.2 × 10(−9), odds ratio = 1.55) with essential tremor. LINGO1 has potent, negative regulatory influences on neuronal survival and is also important in regulating both central-nervous-system axon regeneration and oligo...

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Bibliografski detalji
Glavni autori: Stefansson, Hreinn, Steinberg, Stacy, Petursson, Hjorvar, Gustafsson, Omar, Gudjonsdottir, Iris H, Jonsdottir, Gudrun A, Palsson, Stefan T, Jonsson, Thorlakur, Saemundsdottir, Jona, Bjornsdottir, Gyda, Böttcher, Yvonne, Thorlacius, Theodora, Haubenberger, Dietrich, Zimprich, Alexander, Auff, Eduard, Hotzy, Christoph, Testa, Claudia M, Miyatake, Lisa A, Rosen, Ami R, Kristleifsson, Kristleifur, Rye, David, Asmus, Friedrich, Schöls, Ludger, Dichgans, Martin, Jakobsson, Finnbogi, Benedikz, John, Thorsteinsdottir, Unnur, Gulcher, Jeffrey, Kong, Augustine, Stefansson, Kari
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740956/
https://ncbi.nlm.nih.gov/pubmed/19182806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.299
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