Variant in the sequence of the LINGO1 gene confers risk of essential tremor

We identified a marker in LINGO1 showing genome-wide significant association (P = 1.2 × 10(−9), odds ratio = 1.55) with essential tremor. LINGO1 has potent, negative regulatory influences on neuronal survival and is also important in regulating both central-nervous-system axon regeneration and oligo...

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Hlavní autoři: Stefansson, Hreinn, Steinberg, Stacy, Petursson, Hjorvar, Gustafsson, Omar, Gudjonsdottir, Iris H, Jonsdottir, Gudrun A, Palsson, Stefan T, Jonsson, Thorlakur, Saemundsdottir, Jona, Bjornsdottir, Gyda, Böttcher, Yvonne, Thorlacius, Theodora, Haubenberger, Dietrich, Zimprich, Alexander, Auff, Eduard, Hotzy, Christoph, Testa, Claudia M, Miyatake, Lisa A, Rosen, Ami R, Kristleifsson, Kristleifur, Rye, David, Asmus, Friedrich, Schöls, Ludger, Dichgans, Martin, Jakobsson, Finnbogi, Benedikz, John, Thorsteinsdottir, Unnur, Gulcher, Jeffrey, Kong, Augustine, Stefansson, Kari
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740956/
https://ncbi.nlm.nih.gov/pubmed/19182806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.299
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