Drug Ligand-Induced Activation of Translocator Protein (TSPO) Stimulates Steroid Production by Aged Brown Norway Rat Leydig Cells

Translocator protein (TSPO; 18 kDA) is a high-affinity cholesterol-binding protein that is integrally involved in cholesterol transfer from intracellular stores into mitochondria, the rate-determining step in steroid formation. Previous studies have shown that TSPO drug ligands are able to activate...

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Autori principali: Chung, J.-Y., Chen, H., Midzak, A., Burnett, A. L., Papadopoulos, V., Zirkin, B. R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Endocrine Society 2013
Soggetti:
Reproduction-Development
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740486/
https://ncbi.nlm.nih.gov/pubmed/23525219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2012-2226
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