Age Increase of Estrogen Receptor-α (ERα) in Cortical Astrocytes Impairs Neurotrophic Support in Male and Female Rats

Rodent models show decreased neuronal responses to estradiol (E2) during aging (E2-desensitization) in association with reduced neuronal estrogen receptor (ER)-α, but little is known about age changes of E2-dependent astrocytic neurotrophic support. Because elevated expression of astrocyte glial fib...

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Autori principali: Arimoto, Jason M., Wong, Angela, Rozovsky, Irina, Lin, Sharon W., Morgan, Todd E., Finch, Caleb E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Endocrine Society 2013
Soggetti:
Neuroendocrinology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740484/
https://ncbi.nlm.nih.gov/pubmed/23515288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2012-2046
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