Epigenetic silencing of monoallelically methylated miRNA loci in precancerous colorectal lesions

Epigenetic silencing of protein-encoding genes is common in early-stage colorectal tumorigenesis. Less is known about the methylation-mediated silencing of genes encoding microRNAs (miRNAs), which are also important epigenetic modulators of gene expression. Using quantitative PCR, we identified 56 m...

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Detalhes bibliográficos
Main Authors: Menigatti, M, Staiano, T, Manser, C N, Bauerfeind, P, Komljenovic, A, Robinson, M, Jiricny, J, Buffoli, F, Marra, G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740287/
https://ncbi.nlm.nih.gov/pubmed/23857251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2013.21
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