Autophagy plays a critical role in the degradation of active RHOA, the control of cell cytokinesis and genomic stability

Degradation of signaling proteins is one of the most powerful tumor suppressive mechanisms by which a cell can control its own growth. Here, we identify RHOA as the molecular target by which autophagy maintains genomic stability. Specifically, inhibition of autophagosome degradation by the loss of t...

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Hlavní autoři: Belaid, Amine, Cerezo, Michaël, Chargui, Abderrahman, Corcelle–Termeau, Elisabeth, Pedeutour, Florence, Giuliano, Sandy, Ilie, Marius, Rubera, Isabelle, Tauc, Michel, Barale, Sophie, Bertolotto, Corinne, Brest, Patrick, Vouret-Craviari, Valérie, Klionsky, Daniel J., Carle, Georges F., Hofman, Paul, Mograbi, Baharia
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740229/
https://ncbi.nlm.nih.gov/pubmed/23704209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-4142
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