Autophagy plays a critical role in the degradation of active RHOA, the control of cell cytokinesis and genomic stability

Degradation of signaling proteins is one of the most powerful tumor suppressive mechanisms by which a cell can control its own growth. Here, we identify RHOA as the molecular target by which autophagy maintains genomic stability. Specifically, inhibition of autophagosome degradation by the loss of t...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Belaid, Amine, Cerezo, Michaël, Chargui, Abderrahman, Corcelle–Termeau, Elisabeth, Pedeutour, Florence, Giuliano, Sandy, Ilie, Marius, Rubera, Isabelle, Tauc, Michel, Barale, Sophie, Bertolotto, Corinne, Brest, Patrick, Vouret-Craviari, Valérie, Klionsky, Daniel J., Carle, Georges F., Hofman, Paul, Mograbi, Baharia
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2013
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740229/
https://ncbi.nlm.nih.gov/pubmed/23704209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-4142
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