Autophagy plays a critical role in the degradation of active RHOA, the control of cell cytokinesis and genomic stability

Degradation of signaling proteins is one of the most powerful tumor suppressive mechanisms by which a cell can control its own growth. Here, we identify RHOA as the molecular target by which autophagy maintains genomic stability. Specifically, inhibition of autophagosome degradation by the loss of t...

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Detalhes bibliográficos
Main Authors: Belaid, Amine, Cerezo, Michaël, Chargui, Abderrahman, Corcelle–Termeau, Elisabeth, Pedeutour, Florence, Giuliano, Sandy, Ilie, Marius, Rubera, Isabelle, Tauc, Michel, Barale, Sophie, Bertolotto, Corinne, Brest, Patrick, Vouret-Craviari, Valérie, Klionsky, Daniel J., Carle, Georges F., Hofman, Paul, Mograbi, Baharia
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740229/
https://ncbi.nlm.nih.gov/pubmed/23704209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-4142
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