Pharmacokinetics of ammonium sulfate gradient loaded liposome-encapsulated oxymorphone and hydromorphone in healthy dogs

OBJECTIVE: To evaluate the pharmacokinetics, in dogs, of liposome-encapsulated oxymorphone and hydromorphone made by the ammonium sulfate gradient loading technique (ASG). ANIMALS: Four healthy purpose-bred Beagles aged 9.5 ± 3.2 months and weighing 13.4 ± 2.3 kg. STUDY DESIGN: Randomized cross-over...

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Main Authors: Smith, Lesley J., Kukanich, Butch K., Krugner-Higby, Lisa A., Schmidt, Brynn H., Heath, Timothy D.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740050/
https://ncbi.nlm.nih.gov/pubmed/23601353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/vaa.12042
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