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Pharmacokinetics and Behavioral Effects of an Extended-Release, Liposome-Encapsulated Preparation of Oxymorphone in Rhesus Macaques

The objectives of the study were to determine the pharmacokinetics of oxymorphone (oxy) and of ammonium sulfate-loaded, liposome-encapsulated oxymorphone (LE-ASG oxy) and to evaluate the behavioral effects of both opioid preparations by using ethographic evaluation specific to rhesus monkeys. Rhesus...

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Autors principals: Krugner-Higby, Lisa, KuKanich, Butch, Schmidt, Brynn, Heath, Timothy D., Brown, Carolyn, Smith, Lesley J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Pharmacology and Experimental Therapeutics 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2700165/
https://ncbi.nlm.nih.gov/pubmed/19351868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.150052
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