Iron–Sulfur Cluster Binding by Mitochondrial Monothiol Glutaredoxin-1 of Trypanosoma brucei: Molecular Basis of Iron–Sulfur Cluster Coordination and Relevance for Parasite Infectivity

Aims: Monothiol glutaredoxins (1-C-Grxs) are small proteins linked to the cellular iron and redox metabolism. Trypanosoma brucei brucei, model organism for human African trypanosomiasis, expresses three 1-C-Grxs. 1-C-Grx1 is a highly abundant mitochondrial protein capable to bind an iron–sulfur clus...

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Detalhes bibliográficos
Main Authors: Manta, Bruno, Pavan, Carlo, Sturlese, Mattia, Medeiros, Andrea, Crispo, Martina, Berndt, Carsten, Krauth-Siegel, R. Luise, Bellanda, Massimo, Comini, Marcelo A.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2013
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Forum Original Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3739951/
https://ncbi.nlm.nih.gov/pubmed/23259530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2012.4859
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