5,14-HEDGE, a 20-HETE mimetic, reverses hypotension and improves survival in a rodent model of septic shock: Contribution of soluble epoxide hydrolase, CYP2C23, MEK1/ERK1/2/IKKβ/IκB-α/NF-κB pathway, and proinflammatory cytokine formation

We have previously demonstrated that a stable synthetic analog of 20-HETE, N-[20-hydroxyeicosa-5(Z),14(Z)-dienoyl]glycine (5,14-HEDGE), restores vascular reactivity, blood pressure, and heart rate in endotoxemic rats. The aim of this study was to determine whether decreased renal expression and acti...

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Main Authors: Tunctan, Bahar, Korkmaz, Belma, Sari, Ayse Nihal, Kacan, Meltem, Unsal, Demet, Serin, Mehmet Sami, Buharalioglu, C. Kemal, Sahan-Firat, Seyhan, Cuez, Tuba, Schunck, Wolf-Hagen, Falck, John R., Malik, Kafait U.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3739859/
https://ncbi.nlm.nih.gov/pubmed/23454652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.prostaglandins.2013.01.005
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