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Binding, Conformational Transition and Dimerization of Amyloid-β Peptide on GM1-Containing Ternary Membrane: Insights from Molecular Dynamics Simulation

Interactions of amyloid-β (Aβ) with neuronal membrane are associated with the progression of Alzheimer’s disease (AD). Ganglioside GM1 has been shown to promote the structural conversion of Aβ and increase the rate of peptide aggregation; but the exact nature of interaction driving theses processes...

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Detalhes bibliográficos
Main Authors: Manna, Moutusi, Mukhopadhyay, Chaitali
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3739818/
https://ncbi.nlm.nih.gov/pubmed/23951128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071308
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