MEK5/ERK5 Signaling Suppresses Estrogen Receptor Expression and Promotes Hormone-Independent Tumorigenesis

Endocrine resistance and metastatic progression are primary causes of treatment failure in breast cancer. While mitogen activated protein kinases (MAPKs) are known to promote ligand-independent cell growth, the role of the MEK5-ERK5 pathway in the progression of clinical breast carcinoma remains poo...

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Detalhes bibliográficos
Main Authors: Antoon, James W., Martin, Elizabeth C., Lai, Rongye, Salvo, Virgilo A., Tang, Yan, Nitzchke, Ashley M., Elliott, Steven, Nam, Seung Yoon, Xiong, Wei, Rhodes, Lyndsay V., Collins-Burow, Bridgette, David, Odile, Wang, Guandi, Shan, Bin, Beckman, Barbara S., Nephew, Kenneth P., Burow, Matthew E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3739787/
https://ncbi.nlm.nih.gov/pubmed/23950888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069291
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