IL-7 Promotes T(H)1 Cell Differentiation and Its Level in Serum Predicts Response to Interferon-β in Multiple Sclerosis

The interleukin-7 receptor α chain (IL-7Rα) gene was identified as a top non–major histocompatibility complex–linked risk locus for multiple sclerosis (MS). Recently, we showed that a T helper 1 (TH1)–driven, but not a TH17-driven, form of MS exhibited a good clinical response to interferon-β (IFN-β...

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Hauptverfasser: Lee, Li-Fen, Axtell, Robert, Tu, Guang Huan, Logronio, Kathryn, Dilley, Jeanette, Yu, Jessica, Rickert, Mathias, Han, Bora, Evering, Winston, Walker, Michael G., Shi, Jing, de Jong, Brigit A., Killestein, Joep, Polman, Chris H., Steinman, Lawrence, Lin, John C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3739690/
https://ncbi.nlm.nih.gov/pubmed/21795588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3002400
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