L-type Ca(V)1.2 deletion in the cochlea but not in the brainstem reduces noise vulnerability: implication for Ca(V)1.2-mediated control of cochlear BDNF expression

Voltage-gated L-type Ca(2+) channels (L-VGCCs) like Ca(V)1.2 are assumed to play a crucial role for controlling release of trophic peptides including brain-derived neurotrophic factor (BDNF). In the inner ear of the adult mouse, besides the well-described L-VGCC Ca(V)1.3, Ca(V)1.2 is also expressed....

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Detalhes bibliográficos
Main Authors: Zuccotti, Annalisa, Lee, Sze C., Campanelli, Dario, Singer, Wibke, Satheesh, Somisetty V., Patriarchi, Tommaso, Geisler, Hyun-Soon, Köpschall, Iris, Rohbock, Karin, Nothwang, Hans G., Hu, Jing, Hell, Johannes W., Schimmang, Thomas, Rüttiger, Lukas, Knipper, Marlies
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2013
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3739414/
https://ncbi.nlm.nih.gov/pubmed/23950737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2013.00020
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