Differential Response in Downstream Processing of CHO Cells Grown Under Mild Hypothermic Conditions

The manufacture of complex therapeutic proteins using mammalian cells is well established, with several strategies developed to improve productivity. The application of sustained mild hypothermic conditions during culture has been associated with increases in product titer and improved product quali...

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Hlavní autoři: Tait, Andrew S, Tarrant, Richard D R, Velez-Suberbie, M Lourdes, Spencer, Daniel I R, Bracewell, Daniel G
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2013
Témata:
Bioseparations and Downstream Processing
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3738919/
https://ncbi.nlm.nih.gov/pubmed/23636936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/btpr.1726
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