Two Susceptibility Loci to Takayasu Arteritis Reveal a Synergistic Role of the IL12B and HLA-B Regions in a Japanese Population

Takayasu arteritis (TAK) is an autoimmune systemic vasculitis of unknown etiology. Although previous studies have revealed that HLA-B(∗)52:01 has an effect on TAK susceptibility, no other genetic determinants have been established so far. Here, we performed genome scanning of 167 TAK cases and 663 h...

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Auteurs principaux: Terao, Chikashi, Yoshifuji, Hajime, Kimura, Akinori, Matsumura, Takayoshi, Ohmura, Koichiro, Takahashi, Meiko, Shimizu, Masakazu, Kawaguchi, Takahisa, Chen, Zhiyong, Naruse, Taeko K., Sato-Otsubo, Aiko, Ebana, Yusuke, Maejima, Yasuhiro, Kinoshita, Hideyuki, Murakami, Kosaku, Kawabata, Daisuke, Wada, Yoko, Narita, Ichiei, Tazaki, Junichi, Kawaguchi, Yasushi, Yamanaka, Hisashi, Yurugi, Kimiko, Miura, Yasuo, Maekawa, Taira, Ogawa, Seishi, Komuro, Issei, Nagai, Ryozo, Yamada, Ryo, Tabara, Yasuharu, Isobe, Mitsuaki, Mimori, Tsuneyo, Matsuda, Fumihiko
Format: Artigo
Langue:Inglês
Publié: Elsevier 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3738822/
https://ncbi.nlm.nih.gov/pubmed/23830516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2013.05.024
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