The Multifunctional Ca(2+)/Calmodulin-Dependent Kinase IIδ (CaMKIIδ) Regulates Arteriogenesis in a Mouse Model of Flow-Mediated Remodeling

OBJECTIVE: Sustained hemodynamic stress mediated by high blood flow promotes arteriogenesis, the outward remodeling of existing arteries. Here, we examined whether Ca(2+)/calmodulin-dependent kinase II (CaMKII) regulates arteriogenesis. METHODS AND RESULTS: Ligation of the left common carotid led to...

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Autors principals: Scott, Jason A., Klutho, Paula J., El Accaoui, Ramzi, Nguyen, Emily, Venema, Ashlee N., Xie, Litao, Jiang, Shuxia, Dibbern, Megan, Scroggins, Sabrina, Prasad, Anand M., Luczak, Elisabeth D., Davis, Melissa K., Li, Weiwei, Guan, Xiaoqun, Backs, Johannes, Schlueter, Annette J., Weiss, Robert M., Miller, Francis J., Anderson, Mark E., Grumbach, Isabella M.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3738514/
https://ncbi.nlm.nih.gov/pubmed/23951185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071550
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