Perifosine plus docetaxel in patients with platinum and taxane resistant or refractory high-grade epithelial ovarian cancer

BACKGROUND: On the basis of reversal of taxane resistance with AKT inhibition, we initiated a phase I trial of the AKT inhibitor perifosine with docetaxel in taxane and platinum-resistant or refractory epithelial ovarian cancer. METHODS: Patients with pathologically confirmed high-grade epithelial o...

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Autores principales: Fu, Siqing, Hennessy, Bryan T., Ng, Chaan S., Ju, Zhenlin, Coombes, Kevin R., Wolf, Judith K., Sood, Anil K., Levenback, Charles F., Coleman, Robert L., Kavanagh, John J., Gershenson, David M., Markman, Maurie, Dice, Kristine, Howard, Adrienne, Li, Jane, Li, Yang, Stemke-Hale, Katherine, Dyer, Mary, Atkinson, Edward, Jackson, Ed, Kundra, Vikas, Kurzrock, Razelle, Bast, Robert C., Mills, Gordon B.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3738300/
https://ncbi.nlm.nih.gov/pubmed/22487539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2012.04.006
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