Perifosine plus docetaxel in patients with platinum and taxane resistant or refractory high-grade epithelial ovarian cancer

BACKGROUND: On the basis of reversal of taxane resistance with AKT inhibition, we initiated a phase I trial of the AKT inhibitor perifosine with docetaxel in taxane and platinum-resistant or refractory epithelial ovarian cancer. METHODS: Patients with pathologically confirmed high-grade epithelial o...

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Detalhes bibliográficos
Main Authors: Fu, Siqing, Hennessy, Bryan T., Ng, Chaan S., Ju, Zhenlin, Coombes, Kevin R., Wolf, Judith K., Sood, Anil K., Levenback, Charles F., Coleman, Robert L., Kavanagh, John J., Gershenson, David M., Markman, Maurie, Dice, Kristine, Howard, Adrienne, Li, Jane, Li, Yang, Stemke-Hale, Katherine, Dyer, Mary, Atkinson, Edward, Jackson, Ed, Kundra, Vikas, Kurzrock, Razelle, Bast, Robert C., Mills, Gordon B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3738300/
https://ncbi.nlm.nih.gov/pubmed/22487539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2012.04.006
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