High-dose Valacyclovir Decreases Plasma HIV-1 RNA More Than Standard-dose Acyclovir in HIV-1, HSV-2 Positive Persons: a Randomized, Crossover Trial

BACKGROUND: Standard doses of HSV suppressive therapy reduce plasma HIV-1 RNA levels (0.25-0.53 log(10) copies/mL) among HIV-1/HSV-2 co-infected persons. Postulated mechanisms for this effect include direct inhibition of HIV-1 by acyclovir or indirect reduction by decreasing HSV-associated inflammat...

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Main Authors: Perti, Tara, Saracino, Misty, Baeten, Jared M., Johnston, Christine, Diem, Kurt, Ocbamichael, Negusse, Huang, Meei-Li, Selke, Stacy, Magaret, Amalia, Corey, Lawrence, Wald, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3738066/
https://ncbi.nlm.nih.gov/pubmed/23542637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0b013e3182928eea
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