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High-dose Valacyclovir HSV-2 Suppression Results in Greater Reduction in Plasma HIV-1 Levels Compared With Standard Dose Acyclovir Among HIV-1/HSV-2 Coinfected Persons: A Randomized, Crossover Trial
(See the editorial commentary by Tanton et al, on pages 1822–6.) Background. Standard-dose HSV-2 suppressive therapy (acyclovir 400 mg twice daily) reduces plasma HIV-1 levels by 0.25–0.50 log(10) copies/mL. It is not known if higher doses might further suppress HIV-1 levels. Methods. We enrolled 32...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3247811/ https://ncbi.nlm.nih.gov/pubmed/21998479 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jir649 |
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