Bmp signaling represses Vegfa to promote outflow tract cushion development

Congenital heart disease (CHD) is a devastating anomaly that affects ∼1% of live births. Defects of the outflow tract (OFT) make up a large percentage of human CHD. We investigated Bmp signaling in mouse OFT development by conditionally deleting both Bmp4 and Bmp7 in the second heart field (SHF). SH...

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Bibliographische Detailangaben
Hauptverfasser: Bai, Yan, Wang, Jun, Morikawa, Yuka, Bonilla-Claudio, Margarita, Klysik, Elzbieta, Martin, James F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Company of Biologists 2013
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3737720/
https://ncbi.nlm.nih.gov/pubmed/23863481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.097360
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